Today I am at Manchester Airport awaiting my flight on Lufthansa to Venice via Munich. I have never been to Italy before and until recently would have considered Venice to be a difficult place to visit for a wheelchair user, but research on the internet seemed to suggest otherwise. In the map on the right those areas marked in green are supposed to be fairly easily accessible, those in khaki less accessible, and those in red not accessible. During the next two days I will find out.
Venice has a system of waterbus (Vaporetto) routes that get you around all the islands and they are very wheelchair friendly. The biggest boats, like the one in the photo to the left, run on routes  and  and display the blue wheelchair symbol. There are smaller boats on other routes which I did not see the symbol on but I managed to use every one that I tried and the crews on them were very helpful.
Novotel Venezia Mestre Castellana
Via Ceccherini 21
The Novotel Venezia Mestre Castellana is a 4**** hotel and part of the Accor Hotels group, it is located about 10 kilometres from Venice Marco Polo airport, and about 2 kilometres from Mestre railway station. A taxi there from Marco Polo airport will cost about €40. The hotel has a bar, a restaurant/breakfast room and an outdoor swimming pool. To get in to Venice ‘proper’ you have to take two buses, the number 31H (32H on the return and 34H in both directions on a Sunday) for one stop and then the number 2, they are wheelchair accessible and cost €1.50 for the whole journey. If you choose to take a taxi instead of the bus it is about €30.